Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.
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Viagra works by the quantity of blood flowing through a penis.Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.
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Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.Viagra must be taken specifically as prescribed by your health care supplier. Where Can I Buy Over The Counter Viagra.This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.
The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).